Hardware dedicado para sistemas empotrados de visión

La constante evolución de las Tecnologías de la Información y las Comunicaciones no solo ha permitido que más de la mitad de la población mundial esté actualmente interconectada a través de Internet, sino que ha sido el caldo de cultivo en el que han surgido nuevos paradigmas, como el ‘Internet de las cosas’ (IoT) o la ‘Inteligencia ambiental’ (AmI), que plantean la necesidad de interconectar objetos con distintas funcionalidades para lograr un entorno digital, sensible y adaptativo, que proporcione servicios de muy distinta índole a sus usuarios. La consecución de este entorno requiere el desarrollo de dispositivos electrónicos de bajo coste que, con tamaño y peso reducido, sean capaces de interactuar con el medio que los rodea, operar con máxima autonomía y proporcionar un elevado nivel de inteligencia. La funcionalidad de muchos de estos dispositivos incluirá la capacidad para adquirir, procesar y transmitir imágenes, extrayendo, interpretando o modificando la información visual que resulte de interés para una determinada aplicación. En el marco de este desafío surge la presente Tesis Doctoral, cuyo eje central es el desarrollo de hardware dedicado para la implementación de algoritmos de procesamiento de imágenes y secuencias de vídeo usados en sistemas empotrados de visión. El trabajo persigue una doble finalidad. Por una parte, la búsqueda de soluciones que, por sus prestaciones y rendimiento, puedan ser incorporadas en sistemas que satisfagan las estrictas exigencias de funcionalidad, tamaño, consumo de energía y velocidad de operación demandadas por las nuevas aplicaciones. Por otra, el diseño de una serie de bloques funcionales implementados como módulos de propiedad intelectual, que permitan aliviar la carga computacional de las unidades de procesado de los sistemas en los que se integren. En la Tesis se proponen soluciones específicas para la implementación de dos tipos de operaciones habitualmente presentes en muchos sistemas de visión artificial: la sustracción de fondo y el etiquetado de componentes conexos. Las distintas alternativas surgen como consecuencia de aplicar una adecuada relación de compromiso entre funcionalidad y coste, entendiendo este último criterio en términos de recursos de cómputo, velocidad de operación y potencia consumida, lo que permite cubrir un amplio espectro de aplicaciones. En algunas de las soluciones propuestas se han utilizado además, técnicas de inferencia basadas en Lógica Difusa con idea de mejorar la calidad de los sistemas de visión resultantes. Para la realización de los diferentes bloques funcionales se ha seguido una metodología de diseño basada en modelos, que ha permitido la realización de todo el ciclo de desarrollo en un único entorno de trabajo. Dicho entorno combina herramientas informáticas que facilitan las etapas de codificación algorítmica, diseño de circuitos, implementación física y verificación funcional y temporal de las distintas alternativas, acelerando con ello todas las fases del flujo de diseño y posibilitando una exploración más eficiente del espacio de posibles soluciones. Asimismo, con el objetivo de demostrar la funcionalidad de las distintas aportaciones de esta Tesis Doctoral, algunas de las soluciones propuestas han sido integradas en sistemas de vídeo reales, que emplean buses estándares de uso común. Los dispositivos seleccionados para llevar a cabo estos demostradores han sido FPGAs y SoPCs de Xilinx, ya que sus excelentes propiedades para el prototipado y la construcción de sistemas que combinan componentes software y hardware, los convierten en candidatos ideales para dar soporte a la implementación de este tipo de sistemas.The continuous evolution of the Information and Communication Technologies (ICT), not only has allowed more than half of the global population to be currently interconnected through Internet, but it has also been the breeding ground for new paradigms such as Internet of Things (ioT) or Ambient Intelligence (AmI). These paradigms expose the need of interconnecting elements with different functionalities in order to achieve a digital, sensitive, adaptive and responsive environment that provides services of distinct nature to the users. The development of low cost devices, with small size, light weight and a high level of autonomy, processing power and ability for interaction is required to obtain this environment. Attending to this last feature, many of these devices will include the capacity to acquire, process and transmit images, extracting, interpreting and modifying the visual information that could be of interest for a certain application. This PhD Thesis, focused on the development of dedicated hardware for the implementation of image and video processing algorithms used in embedded systems, attempts to response to this challenge. The work has a two-fold purpose: on one hand, the search of solutions that, for its performance and properties, could be integrated on systems with strict requirements of functionality, size, power consumption and speed of operation; on the other hand, the design of a set of blocks that, packaged and implemented as IP-modules, allow to alleviate the computational load of the processing units of the systems where they could be integrated. In this Thesis, specific solutions for the implementation of two kinds of usual operations in many computer vision systems are provided. These operations are background subtraction and connected component labelling. Different solutions are created as the result of applying a good performance/cost trade-off (approaching this last criteria in terms of area, speed and consumed power), able to cover a wide range of applications. Inference techniques based on Fuzzy Logic have been applied to some of the proposed solutions in order to improve the quality of the resulting systems. To obtain the mentioned solutions, a model based-design methodology has been applied. This fact has allowed us to carry out all the design flow from a single work environment. That environment combines CAD tools that facilitate the stages of code programming, circuit design, physical implementation and functional and temporal verification of the different algorithms, thus accelerating the overall processes and making it possible to explore the space of solutions. Moreover, aiming to demonstrate the functionality of this PhD Thesis’s contributions, some of the proposed solutions have been integrated on real video systems that employ common and standard buses. The devices selected to perform these demonstrators have been FPGA and SoPCs (manufactured by Xilinx) since, due to their excellent properties for prototyping and creating systems that combine software and hardware components, they are ideal to develop these applications

Autoeficacia laboral y las organizaciones saludables: Estudio de la influencia de las variables sociodemográficas

Las organizaciones saludables favorecen las prácticas de la psicología positiva y por lo tanto, mejoran la autoeficacia de los empleados y las probabilidades de éxito en la misión y visión de las organizaciones. Es objetivo realizar una búsqueda bibliográfica para dar una visión más completa de la autoeficacia, enfocándolo en el ámbito laboral. La autoeficacia tiene una amplia relación con la psicología positiva y las organizaciones saludables en la búsqueda del bienestar desde el punto de vista de la salud laboral. Finalmente, se realiza una investigación con la intención de conocer la autoeficacia de los trabajadores en función de distintas variables socio-demográficas, y cómo estas, pueden influir en la autoeficacia.Departamento de PsicologíaGrado en Relaciones Laborales y Recursos Humano

Un algoritmo en tiempo real para etiquetado de componentes conectados en imágenes

Esta comunicación presenta un algoritmo de dos pasadas para el etiquetado en tiempo real de los componentes conexos en una imagen. El algoritmo propuesto es una buena opción frente a otras alternativas de dos y múltiples pasadas ya que ha sido diseñado considerando que su implementación en FPGAs ofrezca un buen compromiso entre recursos ocupados y velocidad de operación. Se describen dos implementaciones hardware de este algoritmo, cuyo desarrollo se ha llevado a cabo siguiendo un flujo de diseño basado en la herramienta System Generator de Xilinx.Comunidad Económica Europea MOBY-DIC FP7-IST- 248858Ministerio de Ciencia e Innovación (España) TEC2008-04920Junta de Andalucía P08- TIC-03674Fondos Feder P08- TIC-0367

Risk factors for unfavorable outcome and impact of early post-transplant infection in solid organ recipients with COVID-19: A prospective multicenter cohort study

The aim was to analyze the characteristics and predictors of unfavorable outcomes in solid organ transplant recipients (SOTRs) with COVID-19. We conducted a prospective observational cohort study of 210 consecutive SOTRs hospitalized with COVID-19 in 12 Spanish centers from 21 February to 6 May 2020. Data pertaining to demographics, chronic underlying diseases, transplantation features, clinical, therapeutics, and complications were collected. The primary endpoint was a composite of intensive care unit (ICU) admission and/or death. Logistic regression analyses were performed to identify the factors associated with these unfavorable outcomes. Males accounted for 148 (70.5%) patients, the median age was 63 years, and 189 (90.0%) patients had pneumonia. Common symptoms were fever, cough, gastrointestinal disturbances, and dyspnea. The most used antiviral or host-targeted therapies included hydroxychloroquine 193/200 (96.5%), lopinavir/ritonavir 91/200 (45.5%), and tocilizumab 49/200 (24.5%). Thirty-seven (17.6%) patients required ICU admission, 12 (5.7%) suffered graft dysfunction, and 45 (21.4%) died. A shorter interval between transplantation and COVID-19 diagnosis had a negative impact on clinical prognosis. Four baseline features were identified as independent predictors of intensive care need or death: advanced age, high respiratory rate, lymphopenia, and elevated level of lactate dehydrogenase. In summary, this study presents comprehensive information on characteristics and complications of COVID-19 in hospitalized SOTRs and provides indicators available upon hospital admission for the identification of SOTRs at risk of critical disease or death, underlining the need for stringent preventative measures in the early post-transplant period

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms underlying the resistance of metastatic lesions to WBRT, we sought to uncover actionable targets and biomarkers that could help to refine patient selection. Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-κB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically or pharmacologically was sufficient to revert the WBRT resistance and increase therapeutic benefits in vivo at lower doses of radiation. In patients with primary melanoma, lung or breast adenocarcinoma developing brain metastasis, endogenous S100A9 levels in brain lesions correlated with clinical response to WBRT and underscored the potential of S100A9 levels in the blood as a noninvasive biomarker. Collectively, we provide a molecular framework to personalize WBRT and improve its efficacy through combination with a radiosensitizer that balances therapeutic benefit and toxicity.info:eu-repo/semantics/publishedVersio

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Appropriateness of antiplatelet therapy for primary and secondary cardio- and cerebrovascular prevention in acutely hospitalized older people

Aims: Antiplatelet therapy is recommended for the secondary prevention of cardio- and cerebrovascular disease, but for primary prevention it is advised only in patients at very high risk. With this background, this study aims to assess the appropriateness of antiplatelet therapy in acutely hospitalized older people according to their risk profile. Methods: Data were obtained from the REPOSI register held in Italian and Spanish internal medicine and geriatric wards in 2012 and 2014. Hospitalized patients aged ≥65 assessable at discharge were selected. Appropriateness of the antiplatelet therapy was evaluated according to their primary or secondary cardiovascular prevention profiles. Results: Of 2535 enrolled patients, 2199 were assessable at discharge. Overall 959 (43.6%, 95% CI 41.5–45.7) were prescribed an antiplatelet drug, aspirin being the most frequently chosen. Among patients prescribed for primary prevention, just over half were inappropriately prescribed (52.1%), being mainly overprescribed (155/209 patients, 74.2%). On the other hand, there was also a high rate of inappropriate underprescription in the context of secondary prevention (222/726 patients, 30.6%, 95% CI 27.3–34.0%). Conclusions: This study carried out in acutely hospitalized older people shows a high degree of inappropriate prescription among patients prescribed with antiplatelets for primary prevention, mainly due to overprescription. Further, a large proportion of patients who had had overt cardio- or cerebrovascular disease were underprescribed, in spite of the established benefits of antiplatelet drugs in the context of secondary prevention

Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

Objectives To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.Design and setting Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.Participants All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.Results A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0–81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51–71); 74.1% men; median length of stay 9 days (IQR 5–19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6–14).Conclusions This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity

Nuevos escenarios para la innovación educativa : el Grupo CREA (Centros en Red para las Enseñanza Activas) y la renovación metodológica de los centros educativos

Convocatoria Proyectos de innovación de Extremadura 2018/2019Proyecto que agrupa a cinco centros educativos: el IES Jaranda (Jarandilla de la Vera, Cáceres), el IESO Sierra la Mesta (Santa Amalia, Badajoz), el IES Albarrega (Mérida, Badajoz), el IESO Val de Xálima (Valverde del Fresno, Badajoz), IESO Matías Ramón Martínez (Burguillos del Cerro, Badajoz) que conforman el Grupo CREA y que comparten una trayectoria común: el uso de metodologías educativas activas. A las iniciativas innovadoras llevadas a cabo colectivamente se suman las individuales de cada centro debido a la particularidad de cada uno de ellos. Los objetivos principales del proyecto son: la creación de una estructura organizativa y de coordinación entre los distintos centros participantes que permita la planificación y puesta en marcha de acciones educativas conjuntas; la introducción de cambios organizativos, funcionales, espaciales y metodológicos para llevar a cabo aprendizajes basados en proyectos, orientados al servicio a la comunidad y a los problemas sociales, centrados en el aprendizaje cooperativo, etc.; el diseño y desarrollo de programas de innovación coordinados entre los distintos centros educativos participantes; el establecimiento de mecanismos de coordinación para hacer efectiva la comunicación, el intercambio de información, el análisis y la reflexión del profesorado participante en los programas de innovación de cada uno de los centros; la formación conjunta del profesorado; el desarrollo de proyectos conjuntos para los alumnos participantes, su conexión en entornos virtuales, el intercambio de experiencias en encuentros periódicos, etc. y la generación y fomento de una nueva red creando un portal web y un espacio de comunicación e intercambio de documentaciónExtremaduraES